10

Feb 2021

CDT Winter Showcase 2021 - Online Event

10 Feb 2021 - 11 Feb 2021

Programme

Day 1 - 10 February 2021

1pm Welcome
Prof Peter Licence 
1.10pm Stereoselective Organocatalytic Reactions
Dr Eoghan McGarrigle, University College Dublin
2.10pm Probing the Redox State of Peptides UsingTunable Polyoxometalate
Cluster  
                 
Heather Damian
2.35pm The Rearrangement and Reaction of Tert-Butyl N-sulfinyl Imines
Oliver Goodrich 
3pm Break 
3.15pm Acyl Phopmsphate Electrophiles From Low Oxidation State Phosphorus
Michael Green  
3.40pm Towards Naphthalene Diimide Metal-Organic Frameworks as Electron Transfer Mediums
Claire Housley
4.05pm Analysis and Formulation of Thermochromic Paints
Akiharu Kitagawa
4.30pm End of Day 1

Day 2 - 11 February 2021

9.30am Welcome to day 2
Prof Hon Lam 
9.35am Process Intensification by Micro-flow and Plasma, Powered by by Challenges from Outer Space and Circularity
Prof Volker Hessel, University of Adelaide
10.35am Polyoxometalates: Multi-Electron Charge Carriers for Redox Flow Batteries
Catherine Peake
11am Break
11.15am Silver and Copper-catalysed Trifluoromethylation of Aryl Iodides
Katie Scott
11.40am Applications of a Catalytic Azide Reduction
Benjamin Scrafield 
12.05pm Bismuth Mediated Meta-Arylation of Phenols
Aaron Senior     
12.30pm Break 
1.30pm The Impact of Synthesis Parameters on Co2Al-CO3 Layered Double Hydroxide Crystal Characteristics and its Subsequent Impact on Adsorption
Jacob Smith
1.55pm Sustainable Protein for Sustainable Aquaculture
Ekaterina Vobovieva
2.20pm The Development of a Reductive Beckmann Rearrangement
James Wilson  
2.45pm Title: TBC
Corinna Schindler, University of Michigan 
3.45pm Mini-presentations - Questions and Discussion
4.30pm Close

 

Key Note Lectures

Eoghan McGarrigle
University College Dublin 

Stereoselective Organocatalytic Reactions

Abstract:

The development of organocatalysts in reactions of carbohydrates including in stereoselective glycosylation reactions will be described (Chem. Sci. 2019, 10, 508; Org. Biomol. Chem. 2019, 17, 7531; Angew. Chem. 2012, 9152). Thioureas and 2-thiouracil have been explored for their capacity to catalyse stereoselective and regioselective glycosylation reactions. Excellent yields and stereoselectivities have been achieved with catalyst loadings down to 0.1 mol%. The scope and limitations of these reactions will be described, as well as details of mechanistic investigations which have led us to conclude that thiourea catalysts don't always activate substrates through Hydrogen-Bonding.

Speaker's biography:

Dr McGarrigle studied chemistry at University College Dublin obtaining his PhD with Declan Gilheany in the area of M(salen) mediated asymmetric epoxidation. Following my PhD, he carried out postdoctoral research developing a method for the synthesis of P-stereogenic phosphorus compounds. This work was patented and has been commercialised by Celtic Catalysts. In 2005, he moved to the University of Bristol as the Research Officer in the group of Varinder Aggarwal. His research in Bristol focused on the development of organosulfur catalysts and reagents in organic synthesis. Two projects from this period have resulted in reagents being made commercially available. In 2009, he was appointed as course manager of the Bristol Chemical Synthesis Doctoral Training Centre. In July 2012, I joined the School of Chemistry in University College Dublin as an independent research group leader funded by Science Foundation Ireland & EU Marie-Curie under the Starting Investigators Research Grant scheme. Following the successful conclusion of that fellowship in July 2016 he was appointed as a lecturer in Organic Chemistry. For more information and for information on opportunities to join his group please see his website: http://mcgarrigleresearch.wordpress.com/.

Prof Volker Hessel
University of Adelaide

Process Intensification by Micro-flow and Plasma, Powered by Challenges from Outer Space and Circularity

Abstract:

Volker Hessel1,2, Nam N. Tran1, Ian Fisk3

1 School of Chemical Engineering and Advanced Materials, University of Adelaide, Australia. 
3 School of Chemical Engineering, University of Warwick, Coventry, UK
2 Division of Food Sciences, School of Biosciences, University of Nottingham,, Loughborough, UK

This presentation will address significant challenges to establishing a long-term human presence in space via fundamentally new chemical engineering for sustainable ‘life-environmental’ systems. Chemical processing in space happens every day (on ISS, 250 miles above) and Space exploration raises already sustainability concerns (e.g. Space debris). So we need a kind of “Green Chemistry”, meaning dedicalted sustainability considerations in space.

Disruptive Technologies have potential for industrial transformation, and can raise sustainability impact in a step change mode. Recent example is the use of continuous-flow for industrial pharmaceutical manufacture, endorsed by the industry stakeholders and FDA. Continuous-flow technology is commonly acclaimed as prime space chemical manufacturing technology, as they effectively work (already on Earth) under microgravity, are encased process units with no headspace, are low-weight, and have large promise for automation [1]. The potential of own-developed recent process intensification concepts (for Earth manufacturing) for disruptive changes in space will be assessed [1,2]: novel process windows, ‘master-solvent enabled factory’, ‘fertilising with wind’, etc.

This includes the proposition of out-of-box concepts such as to use lunar-abundant materials, a lunar circular economy by resource accumulation in plants, near-zero solvent processing, and supply chains determined by environmental constraints.

This disruptive potential will be demonstrated at several space applications: (a) selective solvent extraction of Co vs Ni in flow from mimicked asteroid/planetary ores [1,3] (b) phosphate leaching from mimicked moon crusts, and (c) concepts for space-radiation stable medicinal formulations [4].

Our group is the first to present a circularity definition for chemical manufacturing [5], following the circular transition indicators (circularity mass index, CMI) of the Ellen MacArthur Foundation. The extreme environment conundrum in space and the costs of launching payload and maintaining robust space operations require unprecedented sustainable use of raw materials in holistic circularity. Taking space as ultimate research boundary, scientific discovery will be propelled by interdisciplinary paradigms such as microfluidics, microgravity, space plant growth and lunar minerals processing. We started using an Engineered Closed Circular Life-Environment System (ECCLES) for space farming and have also started research on space food [6].

[1] Hessel et al., Angew Chem Int Ed, 2020. 59, 23

[2] Hessel et al., Chem Eng Sci, 2020. 225, 115774

[3] Wouters, Hessel et al., J Purif Sep Tech, 2020. Accepted

[4] www.nasa.gov/mission_pages/station/research/experiments/explorer/Investigation.html?#id=8307

[5] Escriba-Gelonch, Hessel et al., ACS Sust Chem Eng, 2020. Under review.

[6] Fisk, Hessel et al., J Food Sci, 2020. Submitted

Speaker’s biography:

Prof. Dr. Volker Hessel studied chemistry at Mainz University (PhD in organic chemistry, 1993). In 1994 he entered the Institut für Mikrotechnik Mainz GmbH. In 2002, Prof. Hessel was appointed Vice Director R&D at IMM and in 2007 as Director R&D. In 2005 and 2011, Prof. Hessel was appointed as part-time and full professor at Eindhoven University of Technology, the Netherlands, respectively. In 2018, he was appointed at the University of Adelaide, Australia, as Deputy Dean (Research) at ECMS Faculty and Prof. Pharmaceutical Engineering. He was honorary professor at TU Darmstadt, Germany 2009-2018, and is guest professor at Kunming University of Science and Technology, China (2011-). Prof. Hessel is (co-)author of > 460 peer-reviewed (h index 57). He received the AIChE Award “Excellence in Process Development Research” in 2007, the ERC Advanced Grant “Novel Process Windows” in 2010, the ERC Proof of Concept Grant in 2017, the IUPAC ThalesNano Prize in Flow Chemistry in 2016, and the FET OPEN Grant in 2016. From 2014-2016, Prof. Hessel was authority in the 35-man teamed Enquete Commission “Future of the Chemical Industry” in Germany’s State Parliament in Nordrhine-Westfalia.

Dr Corinna Schindler, University of Michigan 

Abstract &Speaker's Biography - TBC

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